Post by Yara E. Sánchez Corrales

🚨 #NewPreprint Alert! I'm very happy to share our latest research: “Spatially resolved fetal and maternal cell contributions to severe preeclampsia” Now available as a preprint: https://lnkd.in/emjdNgFb This project has been several years in the making, and I’m over the moon to see it come together. #Preeclampsia is a serious gestational disorder, defined by new-onset hypertension and proteinuria. It remains a leading cause of maternal and fetal morbidity and mortality, affecting 2-4% of pregnancies with over 46,000 maternal and 500,000 fetal and neonatal deaths per year . Yet, despite its impact, we still lack a cure or effective treatment. Using #single-cell and #spatial transcriptomics from multiple tissues of the fetal-maternal interface, we characterised both fetal and maternal cellular responses at high resolution. Our results reinforce the central role of the #placenta in preeclampsia and highlight previously novel contributions from maternal immune processes. Thanks to everyone who contributed to this multidisciplinary effort! 😊 Specially, thanks to all the patients who participated in the study. Sara Hillman UCL EGA Institute for Womens Health. Theodorous Xenakis, Leysa Forrest, Jose Moreno, Elizabeth C. R., Lucy Wedderburn, Neil Sebire and Sergi Castellano UCL Faculty of Population Health Sciences UCL Great Ormond Street Institute of Child Health UCL Great Ormond Street Institute of Child Health