Post by Waters Corporation

Researchers from the University of Guelph and University of Toronto  recently published a study in Nature Communications showing how charge detection mass spectrometry (CDMS) can give scientists a clearer view of large protein structures. Using CDMS, the researchers were able to identify the main form of the bacterial proteasome activator Bpa under biologically relevant conditions. This helped them avoid detection bias seen with conventional mass spectrometry and confirm their findings with size-exclusion chromatography. The study gives scientists a better understanding of the relationship between structure and function, while offering new insight into an important antibacterial target. Learn more about how CDMS is helping scientists see what other methods can miss here: https://bit.ly/4ulDsLi