Post by UCL Ventures

New UCL clinical trial evidence shows hormone patches as effective as injections for locally advanced prostate cancer, with fewer side effects. A major UCL-led randomised controlled trial has shown that oestradiol skin patches can control locally advanced prostate cancer just as effectively as standard hormone injections,  while offering meaningful quality of life benefits for patients. Published in The New England Journal of Medicine, the study found that men using patches experienced far fewer hot flushes, lower risks to bone health and cardiovascular markers, and could administer treatment at home, avoiding repeated hospital visits. The trial was led by Professor Ruth Langley at MRC Clinical Trials Unit at UCL, and drew on long running evidence from the PATCH and STAMPEDE trials, recruiting 1,360 men from 75 centres across the UK. It was funded by Cancer Research UK (CRUK) and the UKRI Medical Research Council, and sponsored by Imperial College London and later UCL. As Prostate Cancer UK highlighted, hormone therapy is a cornerstone of prostate cancer care, and these findings could give men greater choice over treatments that fit their lives. At UCLB we’re working to support potential licence applications and engaging with manufacturers to help make this treatment widely available to patients. Dr Richard Fagan, Director of Biopharm, UCLB, said: “This study is a powerful example of how long‑term academic research can lead to real improvements in patients’ lives. We’re supporting Professor Langley and her team to move these findings beyond the clinic by working with potential commercial partners, navigating the licensing landscape and helping lay the groundwork for regulatory approval. Our role is to help ensure promising evidence like this can translate into treatments that are accessible, and ultimately available to the men who could benefit most.” Read more:  https://lnkd.in/ewjucwqk David Phillips Adam Hajjar Richard Fagan  #ProstateCancer #ClinicalTrials #UCL #PatientChoice #LifeSciences #HealthInnovation #Impact