Post by Toni Cathomen

🔬 A new perspective on CRISPR/Cas safety I am pleased to share our newly published Perspective article in #NatureCommunications: “The hidden risks of CRISPR/Cas: structural variations and genome integrity” (Clotilde Aussel, Toni Cathomen & Carla Fuster García) ➡️ We highlight an underappreciated risk dimension of genome editing: >>Large-scale structural variations (e.g., translocations, megabase-scale deletions) >>Links to DNA repair mechanisms and the impact of DNA-PKcs inhibitors >>Implications for clinical safety and translation 📄 Read Open Access: https://lnkd.in/emShqYx3 #CRISPR #GenomeEditing #GeneTherapy #Safety #OffTarget #Genotoxicity #DNARepair Thank you to: X-PAND, Fanconi Cancer Foundation