Post by The Synthetic Chemistry

🔬 Base‑Catalyzed Thiol–Michael Click Reaction ✨ Explore the modular power of the base‑catalyzed thiol–Michael click reaction for rapid construction of thioether linkages. Click chemistry delivers high‑yielding, byproduct‑free transformations, turning complex syntheses into straightforward, reproducible steps that scale effortlessly in the lab and industry. ✓ 🧪 1. Dissolve thiol (1 eq) and methyl acrylate (1.2 eq) in dry THF (0.2 M) under nitrogen, degas 5 min. ✓ 🔗 2. Add triethylamine (10 mol %) and catalytic DMAP (5 mol %); stir 25 °C 1 h, maintaining anhydrous conditions. ✓ ⚙️ 3. Quench with aqueous NH₄Cl, extract ethyl acetate, dry Na₂SO₄, filter, purify thioether product by flash chromatography. 🟢 Has anyone applied this thiol–Michael click for bioconjugation or polymer synthesis? #ClickChemistry #ThiolMichael #BaseCatalyzed #OrganicSynthesis #PolymerScience