Post by Scripps Research

Chemists led by Phil Baran have developed a simpler way to build a tough chemical bond found in some of the world’s best-selling diabetes drugs using common table sugar and vinegar. Working with researchers at the University of Bristol, the team showed that C-glycosides—molecules in which a carbon atom replaces the oxygen that normally links a sugar to another fragment—can be created with a much more straightforward protocol than had historically been used. Using this approach, the team made all of the currently approved SGLT2 inhibitors, several related compounds still in clinical trials, and complex natural products that previously required up to 20 separate synthetic steps to produce. More: https://ow.ly/Oqjr50ZiuG5