Post by The Medical Educator Consortium (MEC), Inc

Name: PIK3CA encodes the p110α subunit of PI3K — the most commonly mutated kinase in human cancer. When mu
Uploaded: 2026-06-27T01:24:54.733Z
Channel: The Medical Educator Consortium (MEC), Inc
Description: PIK3CA encodes the p110α subunit of PI3K — the most commonly mutated kinase in human cancer. When mutated (E545K, H1047R), it becomes a runaway signal telling cells to grow, divide, and evade death.

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PIK3CA encodes the p110α subunit of PI3K — the most commonly mutated kinase in human cancer. When mutated (E545K, H1047R), it becomes a runaway signal telling cells to grow, divide, and evade death. The good news? Researchers at UT Southwestern and around the world are developing next-generation inhibitors that target only the mutated form — sparing healthy cells and reducing side effects. New clinical trials with RLY-2608 and STX-478 are showing early promise. And data from the INAVO120 trial (NEJM 2025) shows that combining PI3K inhibition with hormone therapy and CDK4/6 inhibitors can meaningfully extend survival. Science takes time. But it's working. 💙 #CancerAwareness #BreastCancerResearch #PIK3CA #PI3K #OncologyResearch #CancerScience #UTSouthwestern #SimmonsCancerCenter #ClinicalTrials #ScienceSaturday #CancerFighter #HopeForCancer Teri Valls, CMP, CMM Edgardo S. Santos, MD, FACP, FASCO Luis E Raez Neil Iyengar Irene Kang Alexis LeVee Arya Roy Seth Wander Kay Y.

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