Post by SYNTHESIS Journal

🎉 Published as part of our boryl radical chemistry issue 🎉 ✅ The defluorinative radical borylation of α-(trifluoromethyl)styrenes is a novel access to diverse difluoroalkene-aminoboranes in good yields. ✅Chiara Stavagna and Connie Buettner use a boryl radical precursor borobetaine to give a key boryl radical that reacts with the α-(trifluoromethyl)styrene, forming an initial C–B bond, then a radical-polar crossover mechanism releases fluoride to provide a difluoroalkene product bearing the aminoborane synthetic handle. ✅ Various post-functionalizations demonstrate difluoroalkene-aminoboranes to be valuable building blocks for the construction of complex, high-value molecules. 👀 Read more here: https://lnkd.in/e6gDPvpD