Post by Symeres

When do you stop looking for a lost purse? That's how our Directors of Chemistry describe one of the hardest decisions in hit-to-lead: walking away from a series (and how you never really want to give up). There might not be a single clean rule, but there is a framework and a practical trigger. It's one of a few questions our chemistry team answered recently that didn't make it into the live session. The others are worth your time too. 🔹 When budget limits you to a subset of a library, picking compounds at random is the worst move you can make. And when your target is genuinely novel, library size matters less than structural coverage. 🔹 Carbohydrate scaffolds are still relatively underexplored and complicated, but occasionally they're where interesting IP lives. Have a read and see what our experts have to say about high-quality starting points for drug discovery. 👇 Do you agree? https://lnkd.in/e88GUbva #DrugDiscovery #MedicinalChemistry #DrugDevelopment #SyntheticChemistry