Post by Symeres

How do you move beyond the 50% yield limit typically associated with classical resolution processes for chiral compounds? In this new case study, we share how our team developed a crystallization-induced diastereomeric transformation (CIDT) process for AskAt’s AAT-076, combining diastereomeric salt formation with in situ photochemical racemization to achieve: 🧪 99.0% ee 📈 85% yield ✔️ >99.7% chemical purity 🚫 No recrystallization required The project demonstrates how tailored resolution screening, racemization compatibility and process optimisation can help improve efficiency, reduce waste and support scalable chiral API development. Read the full case study here: https://lnkd.in/dYZHrdnz #DrugDevelopment #ProcessChemistry #CIDT #CMC #SmallMolecule #APIDevelopment #ChiralChemistry #PharmaceuticalDevelopment