Post by Symeres

Are your targets helping you grow, or setting you back? Here are three things that separate targets worth pursuing from those you'll regret.👇 1️⃣ Map the disease biology link before you commit. If the mechanism isn't clear, it will be harder to stay confident further down the line. 2️⃣ Test modulation early, even imperfectly - a rough answer now beats an expensive one at the wrong stage. 3️⃣ Cross-check your evidence across models. Single-study confidence is one of the most common ways programs back the wrong target. Getting these fundamentals right early can save a lot of time, effort, and uncertainty further down the line. 💭 What's the biggest challenge you face when validating new targets?