Post by Symeres

58% of you said you start thinking about scale-up during lead optimization. That's earlier than many teams admit — and it's exactly the right stage to start. Because lead optimization is where decisions lock in manufacturability, cost, and downstream risk. The chemistry you optimize now determines what's possible (and expensive) later. It aligns with what we see in practice 👇 Progress isn't just about making more compounds, it's about making clearer decisions. Every optimisation cycle should answer one question: What are we learning that helps us confidently move forward? If scale-up only gets considered late, teams often end up constrained by choices made much earlier in discovery. 🔗 We break down how experienced teams use data, SAR, and early developability thinking to make smarter lead optimization decisions here: https://brnw.ch/21x3Q2E