Post by Shahrzad Shoushtar

𝐌𝐲 𝐌𝐒𝐜 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐢𝐬 𝐧𝐨𝐰 𝐩𝐮𝐛𝐥𝐢𝐬𝐡𝐞𝐝! https://lnkd.in/gFbhS7_H In this study, we show that treatment with a 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚-𝐭𝐚𝐫𝐠𝐞𝐭𝐞𝐝 𝐚𝐧𝐭𝐢𝐨𝐱𝐢𝐝𝐚𝐧𝐭 (𝐒𝐤𝐐1) attenuates 𝐚𝐩𝐨𝐩𝐭𝐨𝐭𝐢𝐜, but not 𝐧𝐞𝐜𝐫𝐨𝐩𝐭𝐨𝐭𝐢𝐜, signalling in the gastrocnemius muscle of mice with ovarian cancer. Interestingly, despite reducing mitochondrial reactive oxygen species (ROS) and apoptotic signalling, 𝐒𝐤𝐐1 𝐝𝐢𝐝 𝐧𝐨𝐭 𝐩𝐫𝐞𝐯𝐞𝐧𝐭 𝐬𝐤𝐞𝐥𝐞𝐭𝐚𝐥 𝐦𝐮𝐬𝐜𝐥𝐞 𝐰𝐚𝐬𝐭𝐢𝐧𝐠 (cachexia) during ovarian cancer progression. These findings suggest that: 1️⃣ 𝐍𝐞𝐜𝐫𝐨𝐩𝐭𝐨𝐭𝐢𝐜 𝐬𝐢𝐠𝐧𝐚𝐥𝐥𝐢𝐧𝐠 may not be a key contributor to ovarian cancer–induced cachexia  2️⃣ 𝐀𝐩𝐨𝐩𝐭𝐨𝐭𝐢𝐜 𝐬𝐢𝐠𝐧𝐚𝐥𝐥𝐢𝐧𝐠 might influence muscle wasting through mechanisms independent of canonical apoptosis pathways. Of note, while SkQ1 did not rescue muscle mass in this model, a 𝐬𝐞𝐜𝐨𝐧𝐝 𝐩𝐚𝐩𝐞𝐫 from the same parent study published earlier showed that 𝐒𝐤𝐐1 𝐩𝐫𝐞𝐬𝐞𝐫𝐯𝐞𝐝 𝐦𝐮𝐬𝐜𝐥𝐞 𝐬𝐭𝐫𝐞𝐧𝐠𝐭𝐡 𝐩𝐫𝐢𝐨𝐫 𝐭𝐨 𝐚𝐭𝐫𝐨𝐩𝐡𝐲 𝐨𝐧𝐬𝐞𝐭, highlighting its potential in mitigating early functional decline: doi: 10.1016/j.molmet.2025.102211 Thank you to all of our collaborators for their insight and contribution: Luca Delfinis, PhD, Fasih Rahman, Madison Garibotti, Shivam Gandhi, PhD, Aditya Brahmbhatt, Brooke Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Jeffries, PhD, Dr. Zhu-Xu Zhang, Dr. Jeremy Simpson, Joe Quadrilatero, Jim Petrik, and Christopher Perry 😊