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Science Briefing Loss of UFL1 Drives Chromosomal Instability in Prostate Cancer Tumorigenesis Key Highlights Biology · Cell Biology · Cancer This study reveals that loss of the UFL1 gene, a key component of the UFMylation pathway, drives chromosomal instability (CIN) and promotes tumorigenesis in prostate cancer. Researchers demonstrated that UFL1 depletion disrupts mitotic progression and leads to aneuploidy, a hallmark of many cancers....