Post by SCHMIDT + HAENSCH
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💧Small deviations in Ofloxacin enantiomeric composition can affect therapeutic effects, side effects, and pharmacokinetics. That is why reliable optical rotation measurement is essential for pharmaceutical composition control. Pharmacopoeial specifications define narrow optical rotation limits for Ofloxacin, but the exact requirement depends on the referenced standard. The USP–NF Ofloxacin monograph refers to Specific rotation <781S>, with an acceptance range of +1° to −1° for a 10 mg/mL test solution in chloroform. The European Pharmacopoeia Ofloxacin monograph 01/2011:1455 specifies Optical rotation (2.2.7), with an acceptance range of −0.10° to +0.10° using a methanol / methylene chloride sample preparation. 🔬 Different pharmacopoeial references. Different wording. Same requirement for reliable polarimetric measurement. 🧪 The SCHMIDT + HAENSCH VariPol Polarimeter enables fast and reliable measurement of optical rotation under defined conditions of concentration, temperature, wavelength, and optical path length. With integrated Peltier temperature control and Aquisys3 software, the system supports reproducible measurements, secure data management, full traceability, efficient workflows, and compliance with regulations such as 21 CFR Part 11. For pharmaceutical composition control, this supports: ✅ Ofloxacin composition control ✅ Enantiomeric composition monitoring ✅ Optical and specific rotation measurement ✅ Pharmacopeial compliance testing ✅ Consistent pharmaceutical product composition Discover how the SCHMIDT + HAENSCH VariPol Polarimeter supports reliable Ofloxacin optical rotation measurement in pharmaceutical composition control. 💧Check out this application note: https://lnkd.in/dCjKjRVy 🔎 Learn more about the VariPol: https://lnkd.in/dvZGUVqg _________ For more than 160 years, SCHMIDT + HAENSCH has stood for optical precision and analytical measurement technology. Founded in Berlin in 1864 by Franz Schmidt and Herrmann Haensch, we continue to combine German engineering tradition with continuous innovation, supporting laboratories and industrial users worldwide with high-precision instruments for demanding analytical tasks. #VariPol #Polarimetry #Ofloxacin #PharmaceuticalCompositionControl #OpticalRotation #EnantiomericComposition #PharmacopeialCompliance #Aquisys3 #21CFRPart11
