Post by Prinses Máxima Centrum voor kinderoncologie

Matheus Henrique Dias has started as a group leader at the Princess Máxima Center. Together with his team, he is investigating an innovative idea. Instead of inhibiting signals in cancer cells, they aim to further stimulate these signals to overwhelm and kill the cells. This approach is called Therapeutic OVERactivation of oncogenic signaling (TOVER). Together with research groups at the Máxima, Dias focuses on different forms of sarcoma and difficult‑to‑treat pediatric cancers. ‘I hope we can further develop this fundamentally different approach into future treatments, especially for children. They still have their whole lives ahead of them, which makes it important to develop new treatments that are both effective and support an optimal quality of life during and after treatment.'