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140 scientists. One molecule. The manufacturing challenge that pushed chemistry to its limits. The story of enlicitide — macrocycles, the future of drug discovery, and where physics-based simulation fits in. Arianna Elena Maschietto Marius Almstedt Tobias Denzler Eric Hall Adam McGuinness, PhD Mark Adams Ashok Khatri Hal Stern Varun Ramdevan Yannis Pandis Sanjoy Ray Matthias Kaiser Carolina Alarco Djork-Arné Clevert