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GPT-5.4 helped drive a medicinal chemistry project from literature review to a validated experimental result. Paired with molecule.one’s Maria AI and specialized lab, the model proposed an unexpected way to improve a widely used reaction in drug discovery. This is an early example of frontier models supporting more of the scientific research loop: reviewing studies, proposing hypotheses, designing experiments, interpreting data, and surfacing findings that human experts can validate. https://lnkd.in/guSd-DQD

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