Post by Neha Bansal, Ph.D.

New publication alert! 📣 Cupriavidus necator H16 has long been studied for its remarkable metabolic flexibility, particularly its capacity for the sustainable bioproduction of high-value compounds from H2/CO2, formate, and organic waste streams. Yet, when you actually sit down to evaluate the literature, navigating its big genome, genomic redundancy, and complex mixotrophic regulation becomes a true puzzle. As researchers focused on sustainable one-carbon (C1) biomanufacturing and carbon fixation, our next thought was: how do we look past its traditional role as a native bioplastic producer and map out a clear, consolidated view of where the field stands today? Our review paper, “The state of metabolic engineering in the versatile bacterial cell factory Cupriavidus necator H16"-out now in Metabolic Engineering, is our attempt to do exactly that! https://lnkd.in/dJ4TQQr2 To be honest, reading through, organizing, and condensing all of this data into one definitive, cohesive piece was an absolute sprint. I am proud of the depth and quality our team across the Laboratory of Microbiology at Wageningen University & Research(WUR), VTT Technical Research Centre of Finland, and the DTU - Technical University of Denmark (DTU) has managed to compile. Many thanks to my co-authors Tytti Jämsä, Enrico Orsi, Suzan Y., Catarina Rocha, Mariana Arango Saavedra, and Stefano Donati for their brilliant contributions and for bringing the distinct expertise that made this comprehensive overview possible. Collaborating with such a phenomenal, multidisciplinary team has been an amazing experience! A special thanks and shout-out to Nico Claassens for his excellent leadership and initiative in driving this review forward. Read the full open-access review here: https://lnkd.in/dJ4TQQr2 For anyone working in carbon fixation, C1 gas fermentation, and Cupriavidus necator as their microbial chassis, we hope this review serves as a valuable resource for your future engineering strategies! #MetabolicEngineering #SyntheticBiology #CarbonFixation #CupriavidusNecator #Biotechnology #C1Economy #WUR #DTU #VTT