Post by Marcos Sacristán Moraleda

Our latest preprint is now up! It focused on closed-loop neuromodulation for Essential Tremor. This work is a central part of my PhD thesis and marks my first publication as first author. This study was a great collaborative effort between Universidad de Zaragoza, CSIC and Hospital 12 de Octubre. We investigated whether targeting specific phases of the tremor cycle with non-invasive transcutaneous spinal cord stimulation (tSCS) could modulate its severity. To do this, we built a real-time framework that tracks the tremor phase directly from surface EMG signals using an adaptive filtering algorithm, delivering stimulation at precise points during an isometric task. Our findings show that tSCS modulates tremor amplitude in a phase-dependent manner. We also observed a physiological decoupling between amplitude modulation and rhythmic pacing, suggesting independent underlying mechanisms. I invite you to read the full paper and check out the results. If you are working on neural engineering, closed-loop systems, or movement disorders, I would love to hear your feedback, discuss the findings, or explore potential collaborations. Full text available here: https://lnkd.in/eQTgWDFZ