Post by Monzer Amir
Pharmacist | Medication Therapy Management & Patient Care | Community
š **Indirect Thrombin Inhibitors | The Heparin Family** A cornerstone class of anticoagulants in clinical practice: **1ļøā£ UFH (Unfractionated Heparin)** š¹ Also known as a Mucopolysaccharide Polymer š¹ Short half-life ā relatively safer choice in renal impairment š¹ Routes: SC or IV š¹ Requires regular aPTT monitoring š¹ Key adverse effect: Heparin-Induced Thrombocytopenia (HIT) ā ļø Treated with IV Argatroban **2ļøā£ LMWH ā e.g., Clexane (Enoxaparin)** š¹ Longer duration of action than UFH š¹ Dose: 1mg/kg BD or 1.5mg/kg OD š¹ No need for routine frequent monitoring like UFH š Understanding the difference between the two is essential for choosing the right therapy ā especially in patients with renal impairment or a history of HIT. #Pharmacy #Pharmacology #Anticoagulants