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Most Rare Disease in the World: 10 Ultra-Rare Conditions You Should Know About Have you ever wondered what the most rare disease in the world is? Surprisingly, there are over 8,000 known rare diseases worldwide, and most people have never heard of them. According to Rare Diseases International, more than 300 million people globally live with a rare disease. That is a big number for something most of us rarely talk about....

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