Post by The Lister Institute of Preventive Medicine

Today, we learn from #ListerFellow Chris H. Hill that viruses are masters of cell manipulation. His research at the University of York explores how positive-sense RNA viruses use the 3D structure of RNA to hijack host cell ribosomes to make viral proteins. Find out more in our latest conversation with #ListerPrize2025 awardees (link in first comment). Unlike human mRNAs, enteroviral RNAs use highly structured regions called internal ribosome entry sites (IRES) to recruit ribosomes. Understanding exactly how this works is scientifically fascinating - and medically significant. Enteroviruses cause a huge burden of disease worldwide, from the common cold to more severe conditions like viral meningitis and polio. Yet, we still lack targeted antivirals that disrupt viral protein synthesis. 🚀 Lister Prize funding will help Chris build new workflows, collaborations and expertise for in situ structural biology. "The Lister Prize has been transformative," says Chris. "The flexibility of the funding means we can take risks and pursue new directions that would be difficult with more traditional grants." What excites you most about this research? Give Chris a midweek mental boost and share what you love most about this research 👇 --- 🖱️ Follow the Lister Institute for more stories from #ListerFellows and our wider community of biomedical research leaders.