Post by leadXpro AG

𝗛𝗼𝘄 𝗬𝗼𝘂𝗿 𝗠𝗼𝗿𝗻𝗶𝗻𝗴 𝗖𝗼𝗳𝗳𝗲𝗲 𝗧𝗲𝗮𝗰𝗵𝗲𝘀 𝗨𝘀 𝗔𝗯𝗼𝘂𝘁 𝗥𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 This short video illustrates two key concepts in pharmacology — agonists and antagonists — using adenosine and caffeine binding to neuronal adenosine receptors. While adenosine (the agonist) activates the receptor, caffeine (the antagonist) blocks it. In collaboration with Jörg Standfuss' team at PSI Paul Scherrer Institut, our colleague Hannah Glover studies the A2A adenosine receptor with time-resolved serial crystallography experiments using both synchrotrons and XFELs, to better understand receptor and ligand binding dynamics at the molecular level. We foresee the knowledge obtained would improve the structure-based drug discovery process for challenging membrane protein targets. A great example of how everyday molecules can illuminate cutting-edge research! 🔗 https://lnkd.in/dGuxUGwK #leadxpro #PSI #adenosine #crystallography