Post by The Lancet Infectious Diseases

🔥The Lancet Infectious Diseases’ July 2026 Issue is live now! 🔥 📢 This month the issue features DTwP vaccination in Nepalese and Ugandan infants. 💉Sanjeev M Bijukchhe, Natalie G Marchevsky, Freddie Mukasa Kibengo, Arun K Sharma and colleagues conducted parallel, open-label, randomised trials in Uganda and Nepal to compare reduced-dose or delayed three-dose schedules of diphtheria-tetanus-pertussis (DTP)-containing vaccine for non-inferiority or superiority compared with the WHO-recommended schedule. Healthy infants aged 42–50 days were randomised (4:4:4:3:3) to one of five DTP-containing vaccine schedules and one of two booster schedules (9 or 12 months). Primary outcome was pre-booster IgG antibody response against pertussis antigens. 📊 Two-dose schedules at ages 6 and 14 weeks and ages 2 and 4 months did not meet non-inferiority criteria for pertussis antibodies pre-booster, except filamentous haemagglutinin (FHA) in Nepal. Delayed three-dose schedules at ages 2, 3, and 4 months and ages 2, 4, and 6 months produced similar or higher post-primary series and pre-booster responses compared with the WHO schedule, but the WHO schedule achieved higher antibody responses against all pertussis antigens, except FHA in Nepal, at age 3 months. 💡More than 17 different DTP schedules are in use worldwide. Findings support that the WHO DTP schedule is the preferred schedule in high-pertussis-burden settings. Also in this month’s issue: 🔹EDITORIAL: Key facts about the Bundibugyo virus outbreak 🔹 Na-GST-1 adsorbed on Alhydrogel co-administered with different Toll-like receptor agonists in hookworm-naive adults using a controlled human infection model in the USA: a phase 2, double-blind, randomised controlled trial 🔹 Post-discharge sequelae of Lassa fever survivors in Nigeria: an analysis of the LASCOPE prospective cohort 🔹 Review-Accelerating research and development of new vaccines against tuberculosis: 5-year progress on the global roadmap 🔹 Review-Best practice guidelines for viral hepatitis service delivery in prisons 🔹 Correspondence-Estimation of the Ebola outbreak size in the Democratic Republic of the Congo 🔗Read more exciting content in the present issue here: https://bit.ly/4vtW114 🖼️Alt: Cover of The Lancet Infectious Diseases’ July 2026 issue by Daria Lada for the featured article. #antibioticresistance, #DTRGramNegative, #AURISscore, #candidaemia, #trachomacontrol, #azithromycinmassdrugadministration, #hookworm, #vaccination, #lassafever, #postdischargesequelae, #dengue, #transmissiondynamics, #DTwPimmunisation, #infants, #pneumococcalconjugatevaccine, #tuberculosis, #viralheaptitis, #prisons,  #post-tuberculosislung disease, #avianinfluenzaA(H5N1), #disseminatedherpeszoster, #Ebola Sameer S Kadri, Victor Garcia-Bustos, Anna Last, David Diemert, Marie Jaspard, Martin L Hibberd, James Wassil, Elly van Riet, PhD, Yumi Sheehan, Nadine Kronfli, Gregory P Bisson, David M Goldfarb, Shinya Hasegawa, Ruth McCabe