Post by JMSACL (Journal of Mass Spectrometry & Advances in the Clinical Lab)

Source: (Talanta) Developed a sensitive LC-MS/MS method for simultaneous quantification of bupropion and hydroxybupropion in human plasma using UA-DLLME. Optimized parameters yielded high extraction recoveries. Validated method demonstrated linearity, precision, and accuracy, applied in a pharmacokinetic study to classify subjects as CYP2B6 extensive metabolizers, aiding in phenotyping and precision pharmacotherapy.