Post by iBET - Instituto de Biologia Experimental e Tecnológica

[Article Recognized Among the Top 10% Most-Viewed Papers in Protein Science] We are pleased to share that the publication, "On the Humanization of VHHs: Prospective Case Studies, Experimental and Computational Characterization of Structural Determinants for Functionality", a collaborative work between Scripps Research, Merck Healthcare and iBET - Instituto de Biologia Experimental e Tecnológica has been recognized by Protein Science, Wiley as one of the journal's top 10% most-viewed papers published in 2024. In this study, researchers investigated the humanization of camelid-derived single-domain antibodies (#VHHs), an important step in developing these molecules for therapeutic applications. By combining #StructuralBiology, #NextGenerationSequencing, and AlphaFold2-driven protein structure prediction, the team explored how key structural features influence antibody stability, binding affinity, and overall functionality. Congratulations to the research team on this recognition and their contribution to advancing antibody engineering. Read the full publication:  🔗 https://lnkd.in/ezeUsu2G Know more about iBET’s Protein Biophysics:   🔗 https://lnkd.in/edvQQNHE   #ProteinScience #AntibodyEngineering #VHH #Nanobodies #Biotherapeutics #ProteinEngineering #StructuralBiology #TopViewedArticle