Post by Giulio Maria Pasinetti, MD, PhD

Researchers Gregor Bieri, Saul Villeda, et al. "have discovered a mechanism that could explain how exercise improves cognition by shoring up the brain’s protective barrier of blood vessels." "With age, the blood-brain barrier gets leaky, letting harmful compounds enter the brain. This causes inflammation, which is associated with cognitive decline and is seen in conditions like #AlzheimersDisease." "Several years ago, the team identified a brain-rejuvenating enzyme called GPLD1 that mice produced in their livers when they exercised. The enzyme itself, however, cannot cross into the brain, leaving scientists unsure how it delivered its cognitive benefits." "The new study reveals that GPLD1 works through another protein called TNAP. As the mice age, the cells that form the blood-brain barrier accumulate TNAP, which makes it leaky. But when mice exercise, their livers produce GPLD1. It travels to the vessels that surround the brain and trims TNAP off the cells." Learn More in Cell by Cell Press https://lnkd.in/eaJ_D9XP Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature - Gregor Bieri, Karishma Pratt, Ph.D.; Yasuhiro Fuseya, Turan Aghayev, Juliana Sucharov, Alana Horowitz, Amber Philp, Karla Fonseca-Valencia, Rebecca Chu, Mason Phan, Laura Remesal Gomez, Shih-Hsiu Wang, Andrew Yang, Kaitlin Casaletto, Saul Villeda University of California, San Francisco Duke University Medical Center Gladstone Institutes Bakar Aging Research Institute (BARI), University of California, San Francisco, Overview from UCSF  https://lnkd.in/e2VqeB_G