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#IMTEpaper: 𝟮𝟬 𝘆𝗲𝗮𝗿𝘀 𝗼𝗳 𝗺𝗮𝗴𝗻𝗲𝘁𝗶𝗰 𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 – 𝗳𝗿𝗼𝗺 𝗽𝗮𝘁𝗲𝗻𝘁𝘀 𝘁𝗼 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 Magnetic Particle Imaging (MPI) has developed from a conceptual innovation to a clinically relevant imaging modality. It enables real-time 3D visualization of superparamagnetic iron oxide nanoparticles (SPIONs) with high sensitivity and without ionizing radiation. Key advancements have been made in scanner architectures (field-free point and line), reconstruction methods (system matrix-based and x-space), and tracer development. Novel tracers such as magnetosomes and SPION-loaded erythrocytes enhance signal quality and specificity. Applications include cardiovascular imaging, stroke detection, perfusion monitoring, and cell tracking. Integration with MRI or CT provides anatomical context. With the reintroduction of a clinically approved tracer and the emergence of human-scale systems, MPI is approaching clinical translation. Validation through prospective clinical studies remains essential. 𝗖𝗶𝘁𝗮𝘁𝗶𝗼𝗻: Mandy Ahlborg, Thorsten M. Buzug, Franz Wegner. 20 𝘺𝘦𝘢𝘳𝘴 𝘰𝘧 𝘮𝘢𝘨𝘯𝘦𝘵𝘪𝘤 𝘱𝘢𝘳𝘵𝘪𝘤𝘭𝘦 𝘪𝘮𝘢𝘨𝘪𝘯𝘨 – 𝘧𝘳𝘰𝘮 𝘱𝘢𝘵𝘦𝘯𝘵𝘴 𝘵𝘰 𝘱𝘢𝘵𝘪𝘦𝘯𝘵𝘴, Biochemical and Biophysical Research Communications, Volume 781, 2025. DOI: 10.1016/j.bbrc.2025.152510 𝗟𝗶𝗻𝗸: https://lnkd.in/e4QP8g87 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Mandy Ahlborg, Thorsten Buzug, PD Dr. Franz Wegner, EDiR, EBIR 𝗔𝗳𝗳𝗶𝗹𝗶𝗮𝘁𝗶𝗼𝗻𝘀: Fraunhofer IMTE, Lübeck; Institute of Medical Engineering, Universität zu Lübeck, Lübeck; Institute of Interventional Radiology, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany 𝗔𝗰𝗸𝗻𝗼𝘄𝗹𝗲𝗱𝗴𝗲𝗺𝗲𝗻𝘁𝘀: This work was funded by Schleswig-Holstein through the Project "Individualisierte Medizintechnik für bildgestützte, robotische Interventionen (IMTE 2)", Project number: 125 24 009. Fraunhofer-Gesellschaft, Fraunhofer Gesundheit, Christian-Albrechts-Universität zu Kiel, Universität zu Lübeck, Technische Hochschule Lübeck, Hanse Innovation Campus Lübeck, Hansestadt Lübeck, Land Schleswig-Holstein, WTSH GmbH, Universitätsklinikum Schleswig-Holstein