Post by Fabian Frommelt

Biological membranes define the borders of life, separating mammalian cells from their environment. Yet these membranes are not impermeable, they are dynamic interfaces that regulate the flow of chemical matter. Most molecules, including nutrients, vitamins, ions, and drugs, cannot cross these barriers unaided. They rely on membrane transporters to enter cells and organelles. Among the roughly 1,500 transporter proteins encoded in the human genome, the solute carrier (SLC) superfamily is the largest and most diverse. Despite their essential roles in physiology and pharmacology, we still know surprisingly little about how these proteins are organized at the molecular level. Do they encounter the same molecular partners throughout their lifecycle? Are there shared patterns in their interactomes that hint at common regulatory mechanisms or functions? We set out to explore these questions by mapping the molecular social lives of SLC transporters. We are excited to share with you our findings which were published in Molecular Systems biology this week: Download the paper here: https://lnkd.in/d3nhkCzk This was a great collaborative effort of a large team, lead from the Superti-Furga lab at CeMM. Thanks to the RESOLUTE proteomics team Rene Ladurner , Eva Liñeiro Retes , Sabrina L. and Icíar Serrano Sánchez and thanks to all invovled: Giulio Superti-Furga Ulrich Goldmann Tabea Wiedmer Gernot Wolf Álvaro Inglés-Prieto Zuzana Gelova Ann-Katrin Hopp Eirini Christodoulaki Shao Thing Teoh Philipp Leippe Brianda L Santini Manuele Rebsamen Svenja Onstein Christoph Klimek Bárbara Barbosa Anastasiia Pantielieieva Vojtech Dvorak Thomas Hannich Julian Schönbett Gilles Sansig Tamara Mocking Jasper F. Ooms Adriaan P. IJzerman Laura Heitman Peter Sykacek juergen reinhardt André Mueller