Post by Evotec

With OCT1's clinical importance in DDI for the NTI object fenoterol, assessing the OCT1 inhibition potential of your investigational drug is critical to mitigate such risk. In our latest blog, we demonstrate that [¹⁴C]-tetraethylammonium (TEA) is a suitable 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 surrogate probe substrate for the clinically relevant fenoterol when assessing investigational drugs as inhibitors of OCT1 in order to predict their potential for OCT1-mediated drug interactions in the clinic. This work underscores the importance of assessing OCT1 inhibition during drug development to guide downstream decision-making, clinical protocols and drug labelling. 🔗 Read about our work, we recently published in 𝗘𝘅𝗽𝗲𝗿𝘁 𝗢𝗽𝗶𝗻𝗶𝗼𝗻 𝗼𝗻 𝗗𝗿𝘂𝗴 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 & 𝗧𝗼𝘅𝗶𝗰𝗼𝗹𝗼𝗴𝘆, to learn more: https://okt.to/xHJQvm #transporters #DrugDiscovery #ADME #DMPK #theadmetoxspecialists