Post by Eva Hedlund

Delighted to share our latest study now published in Acta Neuropathologica. We revisited the role of β2-microglobulin (β2m) in ALS. Our findings demonstrate that both β2m and HLAs (components of MHC-I) are dynamically regulated in ALS and associated with motor neuron vulnerability. We also show that β2m influences astrocyte reactivity (β2m knockout mice have a massive increase in reactive astrocytes yet motor neurons fare well) and local neuromuscular junction stability, but did not alter disease progression of SOD1G93A ALS mice: https://rdcu.be/flpx0 This work was made possible through a close collaboration with Prof. Staffan Cullheim and an outstanding team of postdoctoral researchers and PhD students, spearheaded by Dr Mélanie Leboeuf. We are also deeply grateful to Prof. Abraham Acevedo Arozena and his team in Tenerife for their invaluable contributions. A sincere thank you to everyone involved!