Post by ESRF - The European Synchrotron

Scientists from the ESRF and the University of Southampton have found a new mechanism to tweak the human #immune response by precisely targeting a particular receptor on immune cells. The goal is to either suppress responses in #autoimmune disease or strengthen them for #cancer immunotherapies. They show how this can be achieved by targeting different parts of the receptor with different strengths. “Antibodies aren’t static; they move, they flex, and they change shape when interacting with other molecules. Beamline #BM29 at the ESRF allows us to capture that dynamic behaviour and directly observe these changes in interaction with targets like FcγRIIB. It gives us a crucial perspective that you simply can’t get from a rigid crystal structure alone", explains Hayden Fisher, scientist on the beamline. The results are out now in the journal Immunity. ➡️https://lnkd.in/eFCF4pQD Hayden Fisher Mark Cragg Ivo Tews

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