Post by Emily Byrd

Happy to share that our latest paper is now published in Protein Science. We applied native ion mobility mass spectrometry combined with biochemical and computational approaches to show how ALS-associated mutations and ionic strength reshape the conformational landscape of the TDP-43 C-terminal domain, uncovering distinct pathways to amyloid assembly and phase separation. Thank you to Antonio Calabrese for supervising this project and our collaborators Joel Crossley, Chalmers Chau and Paolo Actis. 🔗 https://lnkd.in/gz_Y4xEz