Post by EMBL

New research from EMBL & collaborators identifies a robust gut microbiome signature linked to colorectal cancer. In one of the largest single-disease gut microbiome meta-analyses to date, researchers found that this microbial signature was consistent across populations, sequencing methods, and age groups. The study also showed that tumour-associated microbes were detectable in early-stage disease and largely mirrored patterns found in stool samples. A machine-learning classifier could distinguish colorectal cancer from non-cancer microbiomes across datasets, highlighting future potential for microbiome-informed, machine-learning-supported research. The findings also link the colorectal cancer microbiome signature to lower dietary fibre intake, suggesting that fibre supplementation can shift the microbiome away from a cancer-associated profile. https://lnkd.in/eWr9iJdP LUCID Research | Leiden University Medical Center | Selin Pekel | Michael Zimmermann | Georg Zeller