Post by Doris Kaltenecker

🤩 Over the moon to see our work published in Nature Portfolio today. Truly a personal dream come true! In this study, we combined whole-body tissue clearing, light-sheet microscopy and AI-based image analysis to map obesity-associated alterations in peripheral nerves and immune cells across the entire mouse body in 3D. Using this approach, we identified structural alterations in facial nerves associated with diminished sensory responses, as well as molecular changes in the trigeminal ganglion, a key processing hub for sensory neurons. Importantly, we found similar molecular signatures in trigeminal ganglion tissue from obese individuals, highlighting the translational relevance of these findings. What excites me most is not only the biology itself, but the possibility of studying disease at organism-wide scale and single-cell resolution, moving beyond isolated organs toward a more integrated understanding of physiology. I believe that combining imaging, AI and spatial biology will fundamentally transform how we study systemic disease. Huge thanks to Izabela Horvath, Rami Al-Maskari, Ying Chen, Zeynep Ilgın Kolabaş, PhD and all co-authors for the amazing teamwork throughout this project. And a very special thank you to Ali Maximilian Ertürk for his support and for fostering such an ambitious and collaborative environment at Helmholtz Munich Check out the paper here 👉 https://lnkd.in/d6nNKTQV

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