Post by CrystalsFirst

Plates, needles, blocks, prisms...over the years, we have handled protein crystals in many different morphologies and behaviour. Working successfully across such a diversity takes broad expertise, automation and reliable technology. By successfully applying SmartSoak® technology in high-throughput co-structure determination workflows, we generate the structural data that helps medicinal chemistry and structure-based drug design move faster. Our experience spans across: - diverse target classes: E3 ligases, transcription factors, GTPases, helicases, phosphatases, and kinases, - different binding mechanisms: non-covalent and covalent, - different type of ligands: small molecules, macrocycles, molecular glues, and PROTACs. Crystal diversity is part of the job - turning it into actionable structural insight is where expertise matters.