Post by CeMM

🧬 𝗛𝗼𝘄 𝗶𝗻𝗵𝗲𝗿𝗶𝘁𝗲𝗱 𝗗𝗡𝗔 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗰𝗮𝗻 𝗶𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝘁𝗵𝗲 𝗿𝗶𝘀𝗸 𝗼𝗳 𝗰𝗵𝗶𝗹𝗱𝗵𝗼𝗼𝗱 𝗹𝗲𝘂𝗸𝗲𝗺𝗶𝗮 A new study from the group of CeMM Adjunct PI Davide Seruggia at St. Anna Children's Cancer Research Institute (CCRI) reveals how the protein ARID5B helps guide the healthy development of B cells (immune cells) and how inherited changes in this protein may increase the risk of childhood leukemia. Published in 𝘕𝘶𝘤𝘭𝘦𝘪𝘤 𝘈𝘤𝘪𝘥𝘴 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩, the study provides the first detailed picture of ARID5B’s function and reveals how its loss may increase a child's risk of developing B cell leukemia. 🔗 Read more: https://bit.ly/4xZO4CK 📄 Publication: https://bit.ly/43RSc9X 📷 The protein complex formed by ARID5B and its binding partners, as predicted by AlphaFold (© Ana Kutschat, PhD & Davide Seruggia / CCRI). #Leukemia #ChildhoodCancer #CancerResearch