Post by Bio-Works Technologies

📄 Case Study: Overcoming the Elution Dilemma for aggregation-prone mAbs We recently investigated the impact of elution pH and buffer chemistry during the purification of an aggregation-prone monoclonal antibody ("Antibody X"). In our latest application note, we compared WorkBeads™ affimAb Edge against widely used commercial protein A resins to evaluate their ability to control aggregation during the capture step. Look through the summary below to see: 👉 Why citrate buffers outperform glycine-HCl in creating a uniform pH transition. 👉 How optimizing the buffer to Citrate pH 3.5 produced the narrowest elution peak. 👉 The analytical SEC results demonstrating WorkBeads™ affimAb Edge delivering >95% yield and lower aggregate (HMWS) levels compared to competitive resins. #Bioprocessing #CaseStudy #MonoclonalAntibodies #affimAbEdge #Biomanufacturing