Post by BioSpring GmbH

Some oligonucleotides do not fragment the way you might expect. That matters when MS/MS is used for sequence confirmation of therapeutic oligonucleotides. In a new publication in Rapid Communications in Mass Spectrometry, BioSpring’s Christopher Gawlig, together with corresponding author Michael Rühl and co-authors, examined how charge state, base composition, and 2'-ribose modifications influence collision-induced dissociation. The findings can help analytical teams select more suitable MS/MS conditions and strengthen confidence in the characterization of chemically modified oligonucleotide therapeutics. Congratulations to Dr. Christopher Gawlig, Mattis Kaumann , Güngör Hanci, Dr. Barbara Karolina Pfaff, and Dr. Michael Rühl. Read the publication here: https://lnkd.in/dbUA3k2v #BioSpring #MassSpectrometry #Oligonucleotides #MSMS