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#EditorsChoice Read now ➡️ "An Integrated Systems Pharmacology Approach Combining Bioinformatics, Untargeted Metabolomics and Molecular Dynamics to Unveil the Anti-Aging Mechanisms of Tephroseris flammea" by Min Hyung Cho, et al. Cited 2 times | Viewed 985 times. Using an integrated pipeline combining UHPLC-MS/MS metabolomics, network pharmacology, molecular docking, and 100 ns molecular dynamics simulations, this study identified 21 compounds in T. flammea, including flavonoids, phenylpropanoids, and pyrrolizidine alkaloids, linked to 226 skin aging-related targets primarily involving inflammation via AKT1 and RELA, and matrix degradation via MAPK3. In vitro validation confirmed significant antioxidant activity and suppression of IL-6, TNF-α, COX-2, and MMP-1 in UVB-exposed fibroblasts without significant cytotoxicity. The article 👉 https://brnw.ch/21x3Vnp The list 👉 https://brnw.ch/21x3Vnq