Post by Bachem

The growing demand for therapeutic oligonucleotides requires scalable, efficient, and more sustainable manufacturing solutions. Stirred bed technology (SBT) for solid-phase oligonucleotide synthesis (SPOS) represents a significant advancement in oligonucleotide manufacturing. As presented at TIDES USA, by introducing a novel reactor and mixing concept, SBT: Eliminates flow-related inhomogeneities associated with conventional packed-bed systems Ensures uniform reagent distribution through continuous stirring Enhances mass transfer and delivers robust performance across different resin types Importantly, SBT SPOS integrates seamlessly with state-of-the-art downstream and hybrid manufacturing concepts, including enzymatic ligation and MCSGP. With its high efficiency, scalability, and future-readiness, SBT SPOS paves the way for sustainable industrial oligonucleotide production at metric-ton scale - and we are committed to advancing technologies that shape the future of oligonucleotide production. Curious to learn more? Discover the full presentation via the link in the comments. #TIDESUSA #Oligonucleotides #SBTSPOS #SPOS #EnzymaticLigation #MCSGP

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