Post by A*STAR Infectious Diseases Labs - A*STAR IDL

🧪 𝗕𝗿𝗶𝗱𝗴𝗶𝗻𝗴 𝗖𝗵𝗲𝗺𝗶𝘀𝘁𝗿𝘆 𝗮𝗻𝗱 𝗜𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝘁𝗼 𝗔𝗱𝘃𝗮𝗻𝗰𝗲 𝗡𝗼𝘃𝗲𝗹 𝗔𝗻𝘁𝗶𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗧𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀   🌍 𝗔𝗻𝘁𝗶𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗿𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 (𝗔𝗠𝗥) is one of the most pressing global health challenges of our time. As the effectiveness of existing antibiotics continues to decline, there is an urgent need for innovative therapeutic strategies to combat emerging and drug-resistant infections.   At A*STAR Infectious Diseases Labs (A*STAR IDL), Dr Ning Li, 𝗣𝗿𝗶𝗻𝗰𝗶𝗽𝗮𝗹 𝗜𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝘁𝗼𝗿 and Head of the 𝗔𝗻𝘁𝗶𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝗟𝗮𝗯, is leading research at the intersection of 𝗰𝗵𝗲𝗺𝗶𝘀𝘁𝗿𝘆 and 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻 𝗯𝗶𝗼𝗹𝗼𝗴𝘆 to develop 𝗻𝗲𝘅𝘁-𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀 against fungal, bacterial and viral pathogens.   🔬 Taking a highly interdisciplinary approach, Dr Li's team transforms innovative molecular designs into potential therapeutics. Along the way, the team made an unexpected discovery: a compound originally designed as an antibacterial agent failed to inhibit bacterial growth, yet demonstrated highly selective activity against a specific 𝘊𝘢𝘯𝘥𝘪𝘥𝘢 fungal species, 𝗮𝗻 𝗲𝗺𝗲𝗿𝗴𝗶𝗻𝗴 𝗳𝘂𝗻𝗴𝗮𝗹 𝗽𝗮𝘁𝗵𝗼𝗴𝗲𝗻 𝗼𝗳 𝗴𝗿𝗼𝘄𝗶𝗻𝗴 𝗴𝗹𝗼𝗯𝗮𝗹 𝗰𝗼𝗻𝗰𝗲𝗿𝗻 𝗱𝘂𝗲 𝘁𝗼 𝗿𝗶𝘀𝗶𝗻𝗴 𝗱𝗿𝘂𝗴 𝗿𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 𝗮𝗻𝗱 𝗹𝗶𝗺𝗶𝘁𝗲𝗱 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗼𝗽𝘁𝗶𝗼𝗻𝘀.   ✨ What began as an unforeseen result has since evolved into a promising avenue for 𝗽𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗮𝗻𝘁𝗶𝗳𝘂𝗻𝗴𝗮𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀, highlighting how breakthrough innovations can emerge from unexpected findings. This work recently culminated in a publication in 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘥 𝘚𝘤𝘪𝘦𝘯𝘤𝘦.   🚀 This research demonstrates how 𝗰𝘂𝗿𝗶𝗼𝘀𝗶𝘁𝘆-𝗱𝗿𝗶𝘃𝗲𝗻 𝘀𝗰𝗶𝗲𝗻𝗰𝗲, coupled with deep interdisciplinary expertise, can unlock new therapeutic opportunities to combat infectious diseases, strengthen 𝗽𝗮𝗻𝗱𝗲𝗺𝗶𝗰 𝗽𝗿𝗲𝗽𝗮𝗿𝗲𝗱𝗻𝗲𝘀𝘀, and deliver meaningful impact for 𝗴𝗹𝗼𝗯𝗮𝗹 𝗵𝗲𝗮𝗹𝘁𝗵.   👇 𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲 𝗮𝗯𝗼𝘂𝘁 𝗗𝗿 𝗟𝗶'𝘀 𝘄𝗼𝗿𝗸 𝗵𝗲𝗿𝗲: https://lnkd.in/gjJwY46M   Tianjiao Dai | Adrielle Chen | Cynfael Wong | Chloe Esturas Cadag | Zach Yeo Zhong Han | Yenn Chin #ASTARforSG #PandemicPreparedness #InfectiousDiseases #AntimicrobialResistance #AMR #DrugDiscovery #AntifungalResearch #TranslationalResearch #ScientificInnovation