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Halothane, a potent nonflammable inhalational anesthetic, was introduced into clinical practice in the United Kingdom in 1956 and the United States in 1958. Shortly after its release for use, isolated published reports appeared of fatal postoperative hepatic necrosis in patients who had received halothane during surgery. In 1969, a study by William H. Forrest, Jr., M.D., and colleagues was published investigating whether exposure to halothane caused hepatic failure. Revisit "The National Halothane Study and Hospital Outcomes," a Classic Papers Revisited article: https://ow.ly/yFsI50ZjhK3 #anesthesiology #anesthesiologist #anesthesiologists #anesthesia #MedicalResearch

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