Post by Amin El Jarroudi Hammou

🎉 First article published! 🎉 I’m thrilled to share that our work on "Click'n ROPISA" one pot synthesis of fluorescent polypeptide nanoparticles via ROPISA (Ring-Opening Polymerization-Induced Self-Assembly) has just been published in Angewandte Chemie International Edition. In this work, we introduce a one-pot strategy that couples aqueous ROPISA of γ-propargyl-L-glutamate N-carboxyanhydride with copper-catalyzed azide-alkyne cycloaddition (CuAAC) to produce fluorescent polypeptide nanoparticles. This one-pot “Click’n ROPISA” process enables the simultaneous formation of polypeptide nano-objects and covalent incorporation of diverse azido-functionalized fluorophores. The resulting assemblies exhibit tunable emission across the visible spectrum and are accessible at high solids content while maintaining high brightness and structural uniformity. These study pave the way for new biocompatible fluorescent probes for imaging and biosensing applications. Many thanks to all the co-authors Juliette Lavainne Rohit Mangalwedhekar JYOTHIS DEVASIA LAURENT COGNET for their contribution and in special to my supervisors Sebastien Lecommandoux✨, Colin Bonduelle✨ and Chloé Grazon✨for their support and trust on my work. Thanks as well as to Institut des Sciences Moléculaires - ISM (université de Bordeaux, CNRS, Bordeaux INP) and LCPO - Laboratoire de Chimie des Polymères Organiques for the stimulating research environment. Many thanks to European Research Council (ERC) for their trust on project. 🔗 Read the article: https://lnkd.in/gnRq5Avk 🔖 Keywords: #Polymers #Nanoparticles #Fluorescence #ROP #NCA #Chemistry #Nanotechnology #Science #PhD #Research