Post by Amgen

Name: How does drug discovery actually work? At Amgen, small molecule drug discovery is driven by the de
Uploaded: 2026-05-06T13:15:30.554Z
Channel: Amgen
Description: How does drug discovery actually work? At Amgen, small molecule drug discovery is driven by the design–make–test–analyze (DMTA) cycle, a continuous process used to optimize molecules and inform the

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How does drug discovery actually work? At Amgen, small molecule drug discovery is driven by the design–make–test–analyze (DMTA) cycle, a continuous process used to optimize molecules and inform the discovery of potential medicines. In this video, Amgen scientists walk through the life of a molecule and show how modern drug discovery works in practice: ➡️Design: Using chemistry, structural biology, and computational models to propose new molecules ➡️Make: Synthesizing compounds and preparing them for testing ➡️Test: Evaluating potency, selectivity, and ADME properties through assays ➡️Analyze: Using data and AI to refine and redesign the next set of molecules This iterative cycle happens across thousands of compounds and is accelerated by integrated labs, automation, and data science at Amgen San Francisco. The result: faster learning, more informed research decisions, and progress toward potential new medicines for patients.

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