Post by Agirad

🚨 𝐆𝐮𝐢𝐝𝐞𝐥𝐢𝐧𝐞 𝐮𝐩𝐝𝐚𝐭𝐞𝐬: 𝐎𝐄𝐂𝐃 𝐓𝐞𝐬𝐭 𝐆𝐮𝐢𝐝𝐞𝐥𝐢𝐧𝐞𝐬 The OECD has published a significant update to its Test Guidelines portfolio, including 7 𝐧𝐞𝐰, 5 𝐮𝐩𝐝𝐚𝐭𝐞𝐝, 𝐚𝐧𝐝 6 𝐜𝐨𝐫𝐫𝐞𝐜𝐭𝐞𝐝  Test Guidelines. These additions further strengthen the available toolbox for chemical safety assessment, with notable developments in new approach methodologies (NAMs), nanomaterial testing, ecotoxicology, and skin sensitisation. 💡 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬 𝐨𝐟 𝐭𝐡𝐞 7 𝐧𝐞𝐰 𝐓𝐞𝐬𝐭 𝐆𝐮𝐢𝐝𝐞𝐥𝐢𝐧𝐞𝐬: • TG 445A – Cytochrome P450 (CYP) enzyme induction. • TG 446A – ToxTracker gene reporter assay. • TG 454A – Human Glucocorticoid Receptor Transactivation Assay. • TG 127 – Dustiness. • TG 322 – Solubility and dissolution rate of nanomaterials. • TG 255 – Chronic bumblebee toxicity. • TG 256 – Earthworm field studies. 💡 𝐅𝐢𝐯𝐞 𝐓𝐞𝐬𝐭 𝐆𝐮𝐢𝐝𝐞𝐥𝐢𝐧𝐞𝐬 𝐡𝐚𝐯𝐞 𝐛𝐞𝐞𝐧 𝐮𝐩𝐝𝐚𝐭𝐞𝐝, 𝐢𝐧𝐜𝐥𝐮𝐝𝐢𝐧𝐠: • TG 201 – Addition of a new algal species. • TG 429 – New lymph node cell count method. • TG 442D – Inclusion of the alpha-Sens and Epi2SensA methods. • TG 497 – Addition of a new Defined Approach for quantitative Point of Departure (PoD) derivation. • TG 498 – Inclusion of the KeraSkin™ Phototoxicity Assay. 💡𝐒𝐢𝐱 𝐓𝐞𝐬𝐭 𝐆𝐮𝐢𝐝𝐞𝐥𝐢𝐧𝐞𝐬 𝐫𝐞𝐜𝐞𝐢𝐯𝐞𝐝 𝐭𝐞𝐜𝐡𝐧𝐢𝐜𝐚𝐥 𝐜𝐨𝐫𝐫𝐞𝐜𝐭𝐢𝐨𝐧𝐬: • TG 442C, TG 442E, TG 444A, TG 455, TG 494, and TG 496. These updates reflect the continued evolution of OECD Test Guidelines towards more mechanistic, human-relevant, and non-animal approaches while expanding capabilities for nanomaterials and environmental safety assessments. 💬 Which of these new or updated Test Guidelines do you expect will have the greatest impact on regulatory toxicology and chemical risk assessment? #OECD #TestGuidelines #Toxicology #NAMs #RegulatoryScience #ChemicalSafety #Nanomaterials #Ecotoxicology #SkinSensitisation #RiskAssessment #EndocrineDisruption #Genotoxicity