Post by Advanced Prostate Cancer Consensus Conference

Ipsilateral sampling maintains clinically significant cancer detection and reduces overdiagnosis in PI-RADS 4–5 lesions https://lnkd.in/e422mJpy Targeted biopsy💉 (TB) alone misses some clinically significant #ProstateCancer (csPCa) in men with unilateral PI-RADS 4–5 lesions. Adding ipsilateral systematic biopsy (iSB) significantly improves csPCa detection, sensitivity, and identification of adverse pathological features, including cribriform architecture, without the excess overdiagnosis seen with full systematic biopsy. Contralateral systematic sampling provides minimal additional benefit, detecting only one extra csPCa per 75 cores while substantially increasing diagnoses of clinically insignificant prostate cancer (ciPCa). Cassandra Jeavons Yilin Zhang Adrian Marcuzzi Stephen Murphy Sobhan Mardan Miles Mannas Silvia Chang OncoAlert🚨 Silke Gillessen Aurelius Omlin Gil Morgan