Post by Valentina Lind

Excited to share our new study now out in Nature with Jai Sidpra, Darren Hargrave, Michael Fox, Michelle Monje, Frederic Schaper, Alexander Cohen, Kish Mankad, Harith Akram, Andreas Horn, Kristian Aquilina et al. Link to paper: https://lnkd.in/eReN68pF Building on recent preclinical studies in cancer neuroscience, we show that diffuse midline glioma (DMG) patient survival and tumour spread can be at least partially explained by tumour connectivity with a common, underlying brain network. Tumours more connected with this ‘DMG network’ exhibit distinct molecular characteristics known to drive tumour invasion. Excitingly, we provide early evidence that disconnecting tumours from the DMG network may prolong patient overall survival. Thank you to all patients and their families and our funders Cancer Research UK City of London Centre, Cancer Research UK (CRUK), NIHR (National Institute for Health and Care Research), UCL Great Ormond Street Institute of Child Health, UCL Queen Square Institute of Neurology