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Being an astrophysicist by training, Dr. Yawei Hui spent much of his early career in exploring the universe for special celestial objects that emit strong X-rays. With experiences accumulated in computing and analytical modeling, he took a significant turn to focus on designing and implementing HPC/Supercomputing workflow and data management system and algorithms development. Now he is taking on new challenges to apply all his data science expertise to understand biomedical data and develop efficient and powerful systems to accelerate scientific discoveries in childhood diseases.